Synthesis and Characterization of Novel Series of 1,2,4-Triazolo[3,4-b]-1,3,4-Thiadiazole Derivatives of Anilinoacetic Acids as Promising Antioxidant Agents

Volume 2 - Issue 2

Jean Baptiste Nkurunziza and Balakrishna Kalluraya*

Received: March 12, 2018;   Published: March 22, 2018

DOI: 10.32474/AOICS.2018.02.000135

Full Text PDF

To view the Full Article   Peer-reviewed Article PDF

Abstract

The preparation of a novel series of 6-arylaminomethyl-3-substituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles (5) by the cyclocondensation of 5-substituted-4-amino-3-mercapto-1,2,4-triazoles (2) with appropriately substituted anilinoacetic acids (4) employing phosphorous oxychloride is reported. The newly synthesized compounds (5) were screened for their antioxidant activity by DPPH radical scavenging assay and their structures were elucidated on the basis of their 1H-NMR, IR, Mass spectral and elemental analysis. Some of the tested compounds showed good DPPH radical scavenger activities comparable to that of standard BHA.

Keywords: Anilinoacetic acids; 1,2,4-Triazoles; Triazolo-thiadiazoles; Antioxidant activity

Abstract| Introduction| Materials and Methods| Result and Discussion| Conclusion| Acknowledgement| References|